APOPTRAK™ is a small molecule (442 Da) belonging to the anthraquinone family.It is optimally excited at 633 or 647 nm and emission in the far-red/near infra-red (NIR) peaking at 700 nm.
APOPTRAK™ is a useful dye in flow cytometry applications:
APOPTRAK™ benefits from all the advantageous "far-red" spectral properties of its parent, but differs significantly in its rate of entry into LIVE cells. APOPTRAK™ enters LIVE cells slowly and apoptotic cells rapidly, allowing a positive discrimination between these two populations. Key benefits include:-
APOPTRAK™ can bring significant benefits to your application:
in FLOW CYTOMETRY:APOPTRAK™ enters LIVE cells slowly and leaky (apoptotic) cells rapidly, to give a signal intensity difference of between 5- and 10-fold, depending on the cell type and treatment. This allows a positive discrimination between these two populations as shown in the example data below.
Published data (Wiltshire et al, Cytometry 2000) suggests an ability of APOPTRAK™ to discriminate early and late apoptotic cells when used in combination with Annexin V. The example below shows the uptake of APOPTRAK™ in a B cell lymphoma sample carrying a low burden of apoptotic cells. Cells were co-stained with FITC-Annexin V.
BioStatus由Paul Smith,Stefan Ogrodzinski和Laurence Patterson 于2000年成立。
从那时起,该公司有机地成长,形成了一个小型的可持续发展企业,并重新投资于研发,从而创建了三个衍生出来的制药公司-OncoTherics,BioSuspensions和BioTherics。
BioStatus被公认为开发新型远红荧光DNA染料的先驱。客户反馈认为BioStatus品牌是优质产品的代名词,这些产品为研究和诊断增加了真正的价值。
该公司在细胞分析方面提供深入的支持和优质的服务,在市场上被视为利基市场。
2012年10月,英国皇家化学学会授予BioStatus著名的“ 2012年创新团队合作奖”。该奖项是对公司“在药物发现,临床诊断和生命科学领域对新型荧光分子探针和细胞检测技术的全球开发和影响”的认可。